TYPE OF PROJECT STREP
Multiscale Immune System SImulator for the Onset of Type 2 Diabetes integrating genetic, metabolic and nutritional data
Welcome to the website of the project MISSION-T2D
MISSION-T2D aims at developing and validating an integrated, multilevel patient-specific model for the simulation and prediction of metabolic and inflammatory processes in the onset and progress of the type 2 diabetes (T2D).
This mission will be accomplished by setting up a multi-scale model to study the systemic interactions of the involved biological mechanisms (immunological/inflammatory processes, energy intake/expenditure ratio and cell cycle rate) in response to a variety of nutritional and metabolic stimuli/stressors.
The project aims at paving the way for translating validated multilevel immune-metabolic models into the clinical setting of T2D. Indeed, this approach will eventually generate predictive biomarkers from the integration of metabolic, nutritional, immune/inflammatory, genetic and gut microbiota profiles, as well as of clinical data, suitable to be translated into cost-effective mobile-based diagnostic tools.